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doi: 10.1007/s00429-010-0282-9 17 LieberknechtVJunqueiraSCCunhaMPBarbosaTAde SouzaLFCoelhoISet al

However, it has been found that the pathological degradation of BBB hinders the proper delivery and action of therapeutic agents, due to a series of functional, structural, and biochemical changes at both the endothelial level and, consequently, in the perivascular and interstitial space [314]