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A natural quinazoline derivative from marine sponge hyrtios erectus induces apoptosis of breast cancer cells via ROS production and intrinsic or extrinsic apoptosis pathways

181 Similarly, sclareol significantly decreased levels of IL-1, TNF-, and IL-6 in Crohns disease models while upregulating tight junction proteins and preserving mucosal structure, indicating immunomodulatory and barrier-stabilizing roles