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This dysbiosis leads to impaired production of short-chain fatty acids, disruption of the intestinal epithelial barrier (Pessa et al., 2023), reduced differentiation of Tregs, and exaggerated Th2-type immune responses, all of which contribute to heightened skin sensitivity and inflammation (Chen et al., 2024)

4 C & D)

The structure reveals that the side-chain of the -tyrosine amino acid residue is situated in the S1 pocket of the enzyme and that the disulfide bond abuts to the S1 pocket