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Tumor microenvironment Tumor heterogenicity GBM exhibits significant intratumor heterogeneity, driven by clonal evolution and cancer stem cell models

When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27