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Description

During hypoxia-reoxygenation injury, hypoxanthine is reincorporated into adenine nucleotides

A recent study in syngeneic and humanized TNBC mouse model has shown the efficacy of PD-1 blockade combined with HIF-1 and HDAC1 inhibition by PX478 and ENT respectively to reverse the anti-PD-1-resistant TNBC and significantly reduces tumor metabolic activity and metastasis (102, 313)