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In the negative control group (Figure 4A), the liver displayed a normal hepatic architecture characterized by well-organized hepatic cords, intact central veins, and uniformly sized hepatocytes with prominent nuclei and eosinophilic cytoplasm

Further, pre-treatment with selenite significantly prevented the radiation-induced mutation of the hprt locus in AA8 cells

Studies like NeoPAL and CORALLEEN suggest that aromatase inhibitors combined with CDK4/6 inhibitors provide similar long-term survival benefits compared to neoadjuvant chemotherapy but with slightly improved breast conservation rates and fewer chemotherapy-related adverse effects

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