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Beyond the approval of different botulinum toxin preparations for the treatment of sialorrhea, efforts to address the plethora of non-motor symptoms of the disease have not translated to novel PD-specific approvals over the last few years

Furthermore, exosomes derived from mesenchymal stem cells (MSCs) inhibit macrophage inflammation by activating the SIRT1-FXR signaling pathway and reduce NLRP3 inflammasome activation, thereby alleviating IBD inflammation [477, 478]

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