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Budak, MD Associate Professor of Medicine Division of Allergy & Infectious Diseases University of Washington Disclosures : None Learning Objective Performance Indicators List the major classes of antiretroviral medications Explain the mechanism of action with each class of antiretroviral medications Summarize evidence supporting antiretroviral treatment for all people with HIV Describe recommended antiretroviral regimens for treatment-nave individuals and discuss factors to consider when selecting an initial regimen Discuss recommended laboratory studies to obtain at baseline and while monitoring response to therapy Background The availability of highly effective antiretroviral therapy in the mid-1990s transformed HIV from a fatal infection to a manageable, chronic disease

Keap1, a homodimeric protein, acts as a substrate adaptor for the Cullin-3 ubiquitin E3 ligase complex

IGF-1 LR3, or Long-R3-IGF-1, is a lab-made version of insulin-like growth factor-1

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