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Although CRS's pathophysiology has not been completely understood, increased permeability and thickness of choroid due to ischemia, inflammation, or hydrostatic forces have been proposed as the possible mechanism (188)

With a personalized treatment plan involving oral and topical medications, along with Pico laser and medical peels, she experienced a considerable reduction in pigmentation and an improvement in skin tone

It consists of multiple cell types, extracellular matrix components, and signaling molecules that interact to promote cancer cell growth, invasion, metastasis, and treatment resistance (Jin and Jin, 2020)