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Retatrutide is an investigational peptide drug developed by Eli Lilly that acts as a triple agonist, simultaneously targeting three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

Given the cellular heterogeneity of the liver and the complex intercellular crosstalk involved in disease progression (28), we then asked whether GSH depletioninduced suppression of lipogenesis and fibrosis is intrinsic to hepatocytes