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Underlying this metabolic reprogramming is the abnormal activation of core transcription factors such as HIF-1 and NF-B, which regulate the expression of genes related to glycolysis, amino acid catabolism, and fatty acid oxidation, respectively (70)

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All the mice were housed in Laboratory Animal Center of Zhejiang University with stable temperature (23 2 C) and light/dark at the interval of 12 h

Although you might experience slight discomfort during the injection process, it typically dissipates swiftly