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In addition, L-carnitine helps to remove toxic compounds from within the mitochondria, which can accumulate as a result of normal metabolic processes

Solasonine also contributed to the ferroptosis of hepatocellular carcinoma cells by the destruction of the glutathione redox system with increasing lipid ROS levels as well as significantly decreasing the levels of GPX4, GSS mRNA, and protein ( TABLE 1 The metabolites from TCM targeting ferroptosis in animal models or cells

doi: 10.1002/chin.199351337 72

When compounds 1a and d 8 - 1a were used as substrates under S-mediated reaction conditions, the HRMS data showed that the para amide transfer via an intramolecular pathway and the mixed acetamide migration products were not detected