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J Clin Neurosci 14 : 208215

1d was driven by bioisosteric replacement of the fragments bound to subpockets A-C, scaffold-hopping, de novo design, and medicinal chemistry and was facilitated by SZMAP/GamePlan 37 , vBrood 38 , and MOE software 39

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4.9 Environmental obesogens and their impact on adipogenic regulation Environmental obesogens represent endocrine-disrupting chemicals that promote obesity through alterations in adipogenesis and metabolic homeostasis (218, 219)