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Oxidative stress is defined as the imbalance between the production of free radicals and the ability of the organism to defend itself from their harmful effects damaging the plasma membrane, DNA and other cell organelles, inducing apoptosis [27] Oxidative stress markers are circulating significantly higher in PCOS patients than in healthy women, so these can be considered as potential inducers of the PCOS pathology [28]

CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis

NHS access is currently restricted to specialist weight management services for adults meeting defined BMI and comorbidity criteria, and is subject to local commissioning decisions and time-limited use Naltrexone/bupropion (Mysimba) a combination product licensed for weight management as an adjunct to a reduced-calorie diet and increased physical activity in adults with a BMI 30 kg/m, or 27 kg/m with weight-related comorbidities [17] [18] Tirzepatide (Mounjaro) a dual GIP/GLP-1 receptor agonist that has received MHRA approval

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