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(2) generation of kynurenine and downstream metabolites that activate the aryl hydrocarbon receptor (AhR) to induce regulatory pathways

Experimental GPX1 deficiency amplifies certain aspects of aging, namely endothelial dysfunction, vascular remodeling, and invasion of leukocytes in cardiovascular tissue

For wound repair evaluation, a transparent acetate sheet (Sigma-Aldrich, St Louis, MO, USA) was placed on the wound, its perimeter was traced and then sheared along the wound tracing, and the sheared part was weighed