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Watch this webinar: Genes That Impact Your Folate, B12 and Methylation & How To Support Them FREE Download What is MTHFR eBook Based on these multiple clinical trials and studies, the traditional concept of SCCD may need to be modified, as patients with increased tHcy and MMA but within lower level of B12 of current reference range may have disease progression because the current reference range may have been set as too low

As shown in the connected scatterplot in Figure 5 (top), the Sucrosomial B12 formulation rapidly raised circulatory vitamin B12 levels above the deficiency threshold, exceeding 300 pg/mL (borderline level) from day 1, and demonstrated a similar pattern of increasing circulatory vitamin B12 levels over time as observed in the KEMU and LRH studies cohorts, reaching a peak value of 592.7 74.3 at day 7, with all measurements throughout the week being significantly higher than baseline ( p 0.012)

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