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10.1016/j.pain.2011.02.051 67 NishidaK.TakeuchiK.HosodaA.SuganoS.MorisakiE.OhishiA.et al (2018)

the siRNA compound is sufficiently large that it can be cleaved by an endogenous molecule, e.g., by Dicer, to produce smaller siRNA compounds, e.g., siRNAs agents the sense and antisense strands may be chosen such that the double-stranded siRNA compound includes a single strand or unpaired region at one or both ends of the molecule