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A final issue with respect to collagen V mutations and classical EDS is the question of what fraction of patients actually carry mutations in the COL5A1 or COL5A2 genes

are not vitamin B deficient, according to the National Institutes of Health perhaps rendering the shots an unnecessary expense, unless prescribed for medical reasons

Bansode, S

Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements