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[11] Signs and symptoms [edit] When vomiting is severe, it may result in the following: [16] Loss of 5% or more of pre-pregnancy body weight Dehydration, causing ketosis, [17] and constipation Nutritional disorders, such as vitamin B 1 (thiamine) deficiency, vitamin B 6 (pyridoxine) deficiency or vitamin B 12 (cobalamin) deficiency Metabolic imbalances such as metabolic ketoacidosis [16] or thyrotoxicosis [18] Physical and emotional stress Difficulty with activities of daily living Symptoms can be aggravated by hunger, fatigue, prenatal vitamins (especially those containing iron), and diet

Interleukin-10-deficient mice develop chronic enterocolitis

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(ii) xanthine oxidoreductase (XOR) metabolism