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Mitochondria are the powerhouses of the living cells and produce energy primarily via oxidative phosphorylation

For example, Nrf2, a representative antioxidant gene, activates the transcription of ferritin heavy chain 1 (a protein involved in iron storage) and heme oxygenase-1 (a protein involved in heme breakdown) to reduce labile iron and regulate iron metabolism and oxidative stress [15,45]