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Our main organ of detoxification of acidic waste products is the lymphatic system and the liver

The glutaminase encoded by GLS2 can be directly bound and transcriptionally induced by p53, reducing cellular sensitivity to ROS-associated apoptosis, possibly through glutathione-dependent antioxidant defense (Suzuki et al., 2010

In addition, transcription factorsincluding Fos , Junb and Egr1 were also upregulated, which is consistent with our transcriptomic analysis of Caco-2 cells treated with clofazimine (Extended Data Fig

Then, cancer cell invasion into LVs is facilitated by the high interstitial fluid pressure inside the tumor (138) ( Figure 4A )