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doi: 10.1016/j.cell.2020.12.040 172 RyuK

Figure 1 This phenomenon causes high variability of IgG4 that generally prevents it from forming immune complexes under chronic antigen stimulation, which possibly plays a role in inhibiting inflammatory reactions

When your body lacks B12, it produces abnormally large red blood cells that cant carry oxygen efficientlya condition called megaloblastic anaemia, also known as B12 deficiency anaemia or anaemia vitamin deficiency