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Targeting these regenerative pathways offers a promising strategy for treating both cardiac and hepatic injury (213, 214)

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81

Briefly, gel bands were cut into small pieces (1 mm 1 mm) and transferred to sample tubes

The expression profile of genes monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF), tumor necrosis factor receptor type 1 (TNFR1), transforming growth factor-beta-1 (TGF1), collagen type I alpha 1 chain (Col1,) actin alpha 2 smooth muscle (SMA), tissue inhibitor of metalloproteinases 1 (Timp1), and haptoglobin (Hp) associated with non-alcoholic fatty liver disease (NAFLD) were elevated in the livers of mice fed an HFD for 16 weeks compared with those from mice fed the control diet (Fig