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However, most of these probes have visible emission with limited tissue penetration depth, and the red shift of emission wavelength remains challenging 31,32,33,34,35,36,37,38,39,40

Then this interleukin binds CD8+ NKG2D+ T cells to further stimulate IFN- production through JAK1 and JAK3 pathways, forming a positive feedback loop (Figure 1) that destroys anagen hair follicles and leads to alopecia areata (34)