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In endothelial cells, AS-III induces embolization through catheter-directed arterial chemotherapy, activates the epidermal growth factor receptor (EGFR), and subsequently the phosphorylation of AKT, ERK1/2, and growth factor signaling pathways ( in vitro models cannot fully replicate the complex tumor microenvironment in humans, and there exist differences in pathophysiological characteristics between animal models and human tumors

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The principle of ADC is on the basis of monoclonal antibodies, which specifically direct toxic agents to diseased tissue