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Virtual screening of FDA-approved drugs against triose phosphate isomerase from entamoeba histolytica and Giardia lamblia identifies inhibitors of their trophozoite growth phase

It was suggested that Sal A enhanced GSH synthesis due to its activatory effect on CBS and consequent homocysteine conversion to cysteine, which subsequently enhanced antioxidant defence and prevented redox-induced GSH loss, leading to further increase in GSH pool size and GSH/GSSG ratio in hyperlipidemic rats