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In summary, while E-Sol5 boosts RBC glycolysis compared to SAGM, supercooled storage significantly slows RBC metabolism, leading to low lactate production and minimal depletion of 2,3-DPG and ATP pools

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Cicletanine stimulates eNOS phosphorylation and NO production via Akt and MAP kinase/Erk signaling in sinusoidal endothelial cells

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Even so, probiotics should not be treated as one uniform solution

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