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55 TodaMLeungDYMoletSBoguniewiczMTahaRChristodoulopoulosPet al

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In the combined therapy, IMiDs increase the direct toxic effects of CD38 mAbs, including lysosomal-mediated apoptotic pathways, and increase CD38 expression on Treg cells, resulting in enhanced elimination of Treg cells [96, 97]

DEFICIENCIA DE VITAMINA B12 Niveles bajos e insuficientes de vitamina B12 pueden llevar a anemia megaloblstica (no debemos confundir anemia megaloblstica con anemia perniciosa, no toda anemia megaloblstica es perniciosa), y producir sntomas neurolgicos, psiquitricos, cardiovasculares, gastrointestinales, dermatolgicos