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Sofowora A, Ogunbodede E, Onayade A

It has been confirmed that the glycolytic cells show lower sensitivity to Cu toxicity, so we may prevent Cu cell death effects by reprogramming the cellular metabolism to favor glycolysis, and HIF-1 is such a transcription factor to hamper cuproptosis sensitivity due to its hypoxic pathways modulating glycolytic enzymes in tumor cells (Huang et al., 2024)

It is well-established that solid tumors in vivo exhibit exacerbated de novo biogenesis of fatty acids, a phenomenon referred to as neoplastic lipogenesis 293,294,295,296,297,298