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10.3389/fncel.2023.1108339 248 RosinaE.BattanB.SiracusanoM.Di CriscioL.HollisF.PaciniL.et al

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As a serotonin-noradrenaline-dopamine reuptake inhibitor, tesofensine works at the level of the brain by suppressing appetite and increasing resting energy expenditure (your basal metabolic rate)