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Second, and this is the critical change, an alpha-aminoisobutyric acid (Aib) substitution was placed at position 2 of the peptide chain

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A 47 , 110119 (1991)

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In addition, frontostriatal-mediated executive dysfunction, including autonomic dysfunction, cognitive/neurobehavioral abnormalities, sleep disorders and sensory abnormalities are also present in many PD cases [134, 135]

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