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Melatonin ameliorates paclitaxel-induced mice spermatogenesis and fertility defects

These results may explain the ineffectiveness of the 10 M dose of LA treatment, as the increased formation of peptide fragments (particularly LA fragment 2) may share enough similarities to the Zot and zonulin receptor-binding motif (G XXX VQ X G) to competitively inhibit LA binding to EGFR and/or PAR2