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Few ideal properties of the drug that can be administered transdermally require that drug should be essentially non-irritating, dose should be preferably up to 20 mg or less and partition coefficient in octanol / water should be between 1 to 4

Sang, H., et al., Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria

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The question of delivery method becomes relevant when researchers consider their specific goals