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These data, together with the computed reaction endothermicities, indicate significant and complex pH dependencies for these reactions arising from the protonation/deprotonation equilibria of both the oxidant and the target disulfides (Fig

(286) conducted a randomized crossover trial in 28 patients with CKD stages 34, demonstrating that a 4-week Mediterranean diet intervention did not result in elevated serum potassium levels (no significant difference pre- and post-intervention) and maintained stable renal function, confirming the safety and feasibility of the Mediterranean diet in CKD patients