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It could lead to a variety of health complications, including: Blood pressure irregularities Elevated cholesterol (or treatment-resistant high cholesterol) Low body temperature or feeling perpetually cold Fatigue, muscle weakness, or joint pain Heart problems Depression Memory problems Weight gain Infertility, miscarriage, stillbirth, or premature labor Menstrual irregularities Loss or reduction of sex drive Constipation Hair loss Swollen hands, feet, and face Growth of thyroid nodules or increased goiter size Increased risk of infection Some people with hypothyroidism want to stop taking their medication for various reasons: You don't feel better taking medication or have new or worsening symptoms