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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced

This cellular trafficking is fundamental to effective tissue repair, as these cells must reach damaged areas to initiate healing processes

Int J Neurol 2122:163171 Tariq A, Ai J, Chen G, Sabri M, Jeon H, Shang X, Macdonald RL (2010) Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats