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This mechanism is also relevant to minoxidil's effect on hair, though the pathways differ: minoxidil acts as a vasodilator that widens existing blood vessels, while VEGF upregulation promotes the formation of new ones

The four priority biochemical biomarkers recommended by the Biomarkers of Nutrition for Development (BOND) project to detect subclinical vitamin B12 deficiency are total serum vitamin B12, serum holotranscobalamin (holo TC), plasma homocysteine, and serum methylmalonic acid

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At the two-hour mark, a mean change in MAP of +12.1% (range -4.2-32.9%) and vasopressor infusion rates of -25.5% (range -70.2-27%) were recorded