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Compared to the top-down, the bottom-up approach allows precise manipulation of synthesis conditions and, hence, offers more control over CD material structure and properties ( Researchers have reported peroxidase, oxidase, superoxide dismutase, and catalase-like activity in functionalized CDs (Zhu et al., 2014

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However, when APAP is ingested in excessive amounts, the capacity of GSH to neutralize NAPQI becomes overwhelmed, leading to depletion of hepatic GSH stores and accumulation of NAPQI, resulting in oxidative stress, mitochondrial dysfunction, and hepatocellular injury, ultimately culminating in acute liver injury and potential liver failure