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10.1016/j.biomaterials.2011.07.043 205 ParkerA.ShangH.KhurgelM.KatzA

The production of reactive species via PG synthesis pathway contributes significantly to the overall reactive species pool in both pathological and normal states, especially during aging (Nita and Grzybowski, 2016)

Despite a strong mechanistic and preclinical foundation, the clinical application of luteolin has been limited by its poor aqueous solubility, extensive phase II conjugation, and low oral bioavailability (Wang et al., 2024