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To minimize the possibility that hepatic injury will become severe between transaminase measurements, physicians should inform patients of the warning signs and symptoms of hepatotoxicity (e.g., nausea, fatigue, lethargy, diarrhea, pruritus, jaundice, right upper quadrant tenderness, and "flu-like" symptoms), and the appropriate action patients should take if these signs and symptoms appear

PMID: 9873495, DOI: 10.1016/s0960-894x(98)00398-9

Intermittent withdrawal of oxaliplatin for alleviating neurotoxicity during oxaliplatin-based chemotherapy for Japanese patients with inoperable or metastatic colorectal cancer: A phase 2 multicenter study

A: Both MK-677 and Ipamorelin have been shown to be generally well tolerated in clinical and preclinical studies with manageable side effects