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10.3389/fphys.2021.690190 123 ZhangJ.ZhangX

Bioinformatics and statistical analysis Raw data from high-throughput sequencing was qualitatively screened using QIIME software (QiIME 1.9.1)

GLP-1 was shown in an in vitro experiment to protect - cells from methylglyoxal-induced apoptosis, by improving mitochondrial function and suppressing prolonged activation of AMP-dependent protein kinase (AMPK) ( Upon glucose stimulation, the pancreatic -cells release insulin into the circulation from secretory granules, where it is temporarily stored, along with another short peptide called amylin (islet amyloid polypeptide

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