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Complementary natural product-derived strategies include barley leaf supplementation (enriching Bifidobacterium to produce inosine, which activates PPAR signaling and attenuates colitis-associated tumorigenesis) (271) and icariin (a flavonoid from Epimedium ), which not only induces tumor ferroptosis via mitochondrial dysfunction but also synergizes with PD-1 inhibitors by reshaping the gut microbiota to reduce pro-inflammatory Escherichia coli and increase SCFA-producing Ruminococcus (272)