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6 Discussion and perspectives GA is a metabolic-inflammatory disorder characterized by an intricate crosstalk between aberrant FA metabolism and immune dysregulation (237)

F 1 progenies displayed lower foliar glutathione levels than GSH overproducer parental lines (CEMK-9 and TRI-2) but significantly higher levels than in parental Xanthi or NahG

Nature 496(7443):101105 Sourbier C, Ricketts CJ, Liao PJ et al (2019) Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc