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Kidney Int (2019) 95(4):88095

Mitroshina EV, Savyuk MO, Ponimaskin E, Vedunova MV

For instance, intraventricular delivery of the iron chelator DFO led to an improvement in the motor phenotype of R6/2 HD mice (Skouta et al

It was also observed that the expression of truncated sortilin and the small interfering RNA (siRNA)-mediated knockdown of sortilin in primary neurons resulted in the missorting of BDNF to the constitutive pathway, further supporting the finding that sortilin regulates the sorting of BDNF to the RSP [9]