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Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: A new mechanism of action

The percent of oxidized mito-Grx1-roGFP2 in U87vIII CHCHD2 KO cells was decreased by 15.8% compared to that measured in CHCHD2 WT cells, indicating that the pool of glutathione in the mitochondrial matrix of KO cells is more reduced than WT counterparts ( Figure 4C )