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Mechanistic research has investigated GHK-Cu as a regulator of gene expression in dermal fibroblast research models, with broad effects observed across genes involved in extracellular matrix remodeling, copper homeostasis, antioxidant defense, and tissue signaling (Pickart & Margolina, 2018)

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Additionally, we assessed HDAC9 expression at various ages and found that it decreases with age in the hippocampus and PFC, regions critical for learning and memory, suggesting that altered HDAC9 expression may play a role in age-related neuronal dysfunction and cognitive decline