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Phloretin, an antioxidant flavonoid abundant in many plant species is known to arrest the cell cycle and induce apoptosis by counteracting metabolic reprogramming in human glioblastoma cells mediated through activation of p27, downregulation of PDKs and cyclins, and suppression of PI3K/AKT/mTOR signaling

For example, a 70 kg adult might start with 7 to 14 mg daily, split into two doses of 3.5 to 7 mg each

In a 15 year study, elderly humans treated with intermittent courses of epithalamin (the natural polypeptide source of epithalon) had longer survival rates, better cardiovascular health, fewer pulmonary illnesses, improved carbohydrate and lipid metabolism, and better physical endurance compared to controls [4]

Normal epithelial and fibroblast cells treated with Epithalon concentrations ranging from 0.1 to 1 g/ml demonstrated significant telomere elongation through hTERT mRNA upregulation and telomerase enzyme activation