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Finally, NO 3 - efflux from cells could be diminished by the binding of extracellular Al to the cell membrane if Al impairs the structural integrity of plasma membranes and alters their permeability ( FIGURE 2 Rufty et al

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Immunol 139 , 655666.e7 (2017)

It can react with different DNA moieties, including purine, pyrimidine and the deoxyribose backbone, resulting in irreversible mutations, such as single and double chain fracture, crosslinking between or within the chain, base modification and purine loss (16)