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Although there is no clear evidence supporting chronic systemic inflammation as the exact cause of airway remodeling in these conditions, there is evidence that systemic inflammation is associated with airway remodeling (142, 143)

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doi: 10.1089/thy.2015.0087 134 ZhaoLWangHDuX

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In this last case, transmethylation capacity is limited because the tissue distribution of the enzyme is restricted to specific organs (Delgado-Reyes et al., 2001)

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