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Additionally, T-IFNAR1 / tumor-bearing mice exhibited a better response to anti-PD- 1 than WT mice (Chen 2022), which also indicates that IFN-I impedes the efficacy of Immune checkpoint inhibition

Eichholzer M, Steinbrecher A, Kaaks R, Teucher B, Linseisen J, Rohrmann S

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Human biology operates through a network of tightly coordinated systems that allow cells to produce energy, communicate with each other, repair damage, and adapt to environmental stress